The Effect of α2HS Glycoprote in on Lymphocyte Reactivity to Phytohemagglutinin

Abstract
The effect of α2HS glycoprotein on lymphocyte reactivity to phytohemagglutinin (PHA) was investigated. The results show that α2HS glycoprotein, rather than enhancing lymphocyte reactivity to PHA as suggested by earlier correlation studies, inhibits such reactivity. Experiments suggest that this inhibition is unlikely to be the result of α2HS glycoprotein binding either PHA or 3H-thymidine but is more likely to act at the cellular level.