Increased Frequency of HL-A10 in Pemphigus Vulgaris
- 1 December 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 108 (6) , 803-805
- https://doi.org/10.1001/archderm.1973.01620270029007
Abstract
In order to determine if there was an association of pemphigus vulgaris and any antigenic specificity of the HL-A system, 43 unrelated white patients with pemphigus vulgaris were typed for HL-A by the microdroplet lymphocyte cytotoxicity test. HL-A10 was present in 17 of 28 unrelated Jewish patients with pemphigus vulgaris (60.7%) as compared to 19 of 94 Jewish control patients (20.2%) (P<.0001). Among female patients, the occurrence of HL-A10 was 71% and among male patients, 45%. HL-A10 was elevated but not significantly associated with pemphigus vulgaris in non-Jewish whites. No significant associations were noted for other HL-A specificities. A pemphigus susceptibility gene linked to HL-A is postulated.Keywords
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