Lipase-promoted asymmetric transesterification of 4-alkyloxetan-2-ones with ring-opening
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 13,p. 1645-1646
- https://doi.org/10.1039/p19950001645
Abstract
Lipase-catalysed reaction of (±)-4-alkyloxetan-2-ones 1a–c with benzyl alcohol gave (R)-1a(R = Me)(36%, 96% ee) and benzyl (S)-3-hydroxybutanoate 2a(51%, 85% ee), (R)-1b(R = Pr)(42%, 75% ee) and benzyl (S)-3-hydroxyhexanoate 2b(45%, 69% ee) and (S)-1c(R = Pri, 41%, 95% ee) and benzyl (R)-3-hydroxy-4-methylpentanoate 2c(43%, 90% ee), respectively.Keywords
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