C2-α-Lactylthiamin Diphosphate Is an Intermediate on the Pathway of Thiamin Diphosphate-dependent Pyruvate Decarboxylation
Open Access
- 1 December 2004
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 279 (52) , 54312-54318
- https://doi.org/10.1074/jbc.m409278200
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- Tetrahedral Intermediates in Thiamin Diphosphate-Dependent Decarboxylations Exist as a 1‘,4‘-Imino Tautomeric Form of the Coenzyme, Unlike the Michaelis Complex or the Free CoenzymeBiochemistry, 2004
- Fragmentation of the Conjugate Base of 2-(1-Hydroxybenzyl)thiamin: Does Benzoylformate Decarboxylase Prevent Orbital Overlap To Avoid It?Journal of the American Chemical Society, 2003
- Dual Catalytic Apparatus of the Thiamin Diphosphate Coenzyme: Acid−Base via the 1‘,4‘-Iminopyrimidine Tautomer along with Its Electrophilic RoleJournal of the American Chemical Society, 2003
- NMR Analysis of Covalent Intermediates in Thiamin Diphosphate EnzymesBiochemistry, 2003
- Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactionsNatural Product Reports, 2003
- Interplay of organic and biological chemistry in understanding coenzyme mechanisms: example of thiamin diphosphate‐dependent decarboxylations of 2‐oxo acidsFEBS Letters, 1999
- Sixty years of thiamin diphosphate biochemistryBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
- Thiamin diphosphate: a mechanistic update on enzymic and nonenzymic catalysis of decarboxylationChemical Reviews, 1987
- Interaction of pyruvate-thiamin diphosphate adducts with pyruvate decarboxylase. Catalysis through "closed" transition statesJournal of the American Chemical Society, 1981
- On the Mechanism of Thiamine Action. IV.1 Evidence from Studies on Model SystemsJournal of the American Chemical Society, 1958