Synthesis of Sterically Demanding α-Amino-β-Hydroxy Acids via anti-Selective Aldol Reactions
- 1 September 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (09) , 945-946
- https://doi.org/10.1055/s-1995-5119
Abstract
Titanium enolates of N-(benzyloxycarbonyl) amino acid esters react with aldehydes to give anti-isomers of α-alkylated α-amino-β-hydroxy acids. Best results were obtained with bulky aliphatic aldehydes and sterically demanding amino acids.Keywords
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