Effect of Intravascular Isotope Content on the Isotopic Determination of Coronary Collateral Blood Flow

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Abstract
Simultaneous determinations of myocardial blood volume (using I 131 -PVP), myocardial blood flow (using H 3 2 O), and coronary collateral myocardial blood flow (using retrograde flow) were made in dogs after left circumflex artery ligation. Intravascular H 3 2 O content at the end of the H 3 2 O infusion was calculated as the product of myocardial blood volume and the final arterial H 3 2 O concentration. When correction is made for intravascular H 3 2 O content the resulting flow measured by H 3 2 O is nearly identical to the retrograde flow. These results indicate that radioactive isotopes can be used to measure blood flow if correction is made for the intravascular isotope content. The identity of corrected H 3 2 O flows with retrograde flows also indicates the applicability of isotopic methods for the measurement of coronary collateral blood flow.