Adrenocorticotropic Hormone Causes Long-Lasting Potentiation of Transmitter Release from Frog Motor Nerve Terminals

3 June 1983

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 220 (4601) , 1071-1072
https://doi.org/10.1126/science.6133353

Abstract

Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.

This publication has 17 references indexed in Scilit:

In vitro effect of adrenocorticotrophic hormone on the ph profile of tri- and diester lipase activities from rat brain
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
On the Neurochemical Mechanism of Action of ACTH
Published by Elsevier ,1980
ACTH‐SENSITIVE PROTEIN KINASE FROM RAT BRAIN MEMBRANES
Journal of Neurochemistry, 1979
The Behaviorally Active Neuropeptide ACTH as Neurohormone and Neuromodulator: The Role of Cyclic Nucleotides and Membrane Phosphoproteins
Published by Springer Nature ,1979
ACTH-induced inhibition of endogenous rat brain protein phosphorylation in vitro: Structure activity
Neurochemical Research, 1978
PLASMA ACTH LEVELS IN STRESSED AND NONSTRESSED ADRENALECTOMIZED RATS
Annals of the New York Academy of Sciences, 1977
Calcium-dependent presynaptic action of substance P at the frog neuromuscular junction
Nature, 1977
ACTH and neuromuscular transmission: Electrophysiological in vitro investigation of the effects of corticotropin and an ACTH fragment on neuromuscular transmission
Annals of Neurology, 1977
Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction.
The Journal of Physiology, 1976
The effect of corticotropin on the neuromuscular junction
Neurology, 1968