Hindlimb extensor reflex of spinal rats given tranylcypromine stereoisomers

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Abstract
The hindlimb extensor reflex of reserpinized, spinal rats was used to determine whether tranylcypromine (dl-TCP) and its Stereoisomers (d-TCP andl-TCP) affect tryptaminergic neurotransmission.dl-TCP andd-TCP caused an extensor reflex whilel-TCP failed to cause a reliable extensor reflex. Neither H 22/54 nor nialamide affected the extensor reflex in rats givendl-TCP, while H 22/54 reduced the reflex in rats givend-TCP. The results suggest thatdl-TCP andd-TCP have direct as well as indirect actions on tryptaminergic neurotransmission.