The Pharmacological Influence on Thrombocyte Aggregation in the Extracorporeal Circulation of Dogs

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Abstract
The purpose of this study was to investigate the effect of a thrombocyte aggregation-inhibitor on the fall in thrombocyte count during extracorporeal circulation in dogs. When extracorporeal circulation had been established, the thrombocyte count observed during the 2-hour experiment with a flow of approximately 20 ml/kg/min showed an average fall of more than 50% of the initial value. This was reduced to 25% by administering a Dipyridamol-derivative (5 mg/kg RA 233, Thomae, Biberach). According to current views loss of thrombocytes during extracorporeal circulation is mainly due to aggregation, although there are other contributary factors such as loss of blood, destruction of thrombocytes, dilution in the system, and deposits of thrombocytes on parts of the heart-lung machine. We suppose that the fall in thrombocytes may be affected favourably by administering an aggregation inhibitor.

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