Expression of the IGF-ll/mannose-6-phosphate receptor mRNA and protein in the developing rat
Open Access
- 1 May 1990
- journal article
- Published by The Company of Biologists in Development
- Vol. 109 (1) , 67-73
- https://doi.org/10.1242/dev.109.1.67
Abstract
The insulin-like growth factor II (IGF-II) receptor is identical to the mannose-6-phosphate receptor (M-6-P), but its role as a somatomedin transducer is uncertain. IGF-II/M-6-P receptor expression was studied by in situ hybridization (ISH) in the developing rat. Expression occurs in extra-embryonic membranes at the time of IGF-n mRNA induction and later at paracrine/ autocrine sites of IGF-II action (skeletal muscle and perichondrium) in the embryo. Highest levels of receptor mRNA occur in heart and major vessels. Postnatally transcription is strongly down-regulated. This suggests a role for the IGF-II/M-6-P receptor in IGF-II action or turnover during development distinct from its role in lysosomal transport.Keywords
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