Endothelin-1 Facilitates Synaptic Transmission in the Nucleus Tractus Solitarii in Normotensive Rats but Not in Spontaneously Hypertensive Rats.
- 1 January 1999
- journal article
- research article
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 22 (1) , 43-48
- https://doi.org/10.1291/hypres.22.43
Abstract
We previously demonstrated that endothelin-1 (ET-1) increases the neuronal activity of neurons in the nucleus tractus solitarii (NTS) and augments the response to glutamate (Glu), using in vitro brainstem slice preparations of normotensive Wistar-Kyoto (WKY) rats. This study was designed to determine whether the effects of ET-1 on neuronal activity and synaptic transmission in the NTS are altered in spontaneously hypertensive rats (SHR). Experiments were performed with WKY rats and age-matched SHR. We recorded the extracellular single unit of neuronal activity of NTS neurons in response to electrical stimulation of the solitary tracts using in vitro brainstem slice preparations. ET-1 or Glu was iontophoretically applied to the recording neurons. ET-1 increased the neuronal activity of NTS neurons in SHR as well as WKY. The magnitude of the increase in the neuronal activity evoked by Glu was augmented by application of ET-1 in WKY rats (6.1±0.6 to 11.1±1.7spikes/s, pHypertens Res 1999; 22: 43-48)Keywords
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