Purine Studies. XXII. Occurrence of N- and C-Methylation on Diazomethane Treatment of 2-Methylthiopurine
- 1 January 1979
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 32 (12) , 2771-2776
- https://doi.org/10.1071/ch9792771
Abstract
Diazomethane treatment of 2-methylthiopurine gives the expected 9- methyl-2-methylthiopurine as the main product together with a smaller amount of the 7-methyl isomer. An unexpected feature of this reaction, however, is the formation also, in smaller but significant yields, of C,N-dimethylated homologues, identified as 7,8- and 8,9-dimethyl-2- methylthiopurine. Subsequent methylation studies point towards the 8-methyl group in the latter derivatives being introduced prior to the N-methylation step, thus representing an additional alkylation pathway for some purine derivatives.Keywords
This publication has 1 reference indexed in Scilit:
- Purine studies. XVIII. The C- and N-alkylation of theophylline and derivativesAustralian Journal of Chemistry, 1976