Expression of Lymphocytes FcεRII/CD23 in Allergic Children Undergoing Hyposensitization
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 101 (2) , 203-208
- https://doi.org/10.1159/000236520
Abstract
Owing to the proposed role of FcεRII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus(Dpt) before and 6 weeks after hyposensitization. FACS analysis of double, direct immunofluorescence staining of the whole blood revealed an elevated percentage of FcεRII/CD23+ lymphocytes in allergic children (10.29 ± 5.0), a significantly higher percentage than in nonallergic children (5.7 ± 2.4, p Dpt-specific IgG4 and IgE remained unchanged.Keywords
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