Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24-dihydroxycholecalciferol
- 1 October 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 115 (4) , 431-433
- https://doi.org/10.1111/j.1365-2133.1986.tb06237.x
Abstract
We treated 11 psoriatic patients with topical 1.alpha.,24-dihydroxycholecalciferol, a new synthetic analogue of active vitamin D3. In 10 of 15 tests the lesions cleared completely within 1-4 weeks, although some relapses occurred shortly after cessation of treatment. There were no side-effects. We suggest that 1.alpha.,24(OH)2D3 merits further investigation as a potentially useful topical therapy for psoriasis.This publication has 6 references indexed in Scilit:
- Topical administration of 1,25-dihydroxyvitamin D3 for proriasis: Report of five casesCalcified Tissue International, 1986
- Possible Functions of 1α,25-Dihydroxyvitamin D3, an Active Form of Vitamin D3, in the Differentiation and Development of SkinJournal of Investigative Dermatology, 1985
- 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress invitro antibody response to T cell-dependent antigenBiochemical and Biophysical Research Communications, 1985
- Regulation of Terminal Differentiation of Cultured Mouse Epidermal Cells by lα,25-Dihydroxyvitamin D3*Endocrinology, 1983
- DEMONSTRATION OF 1,25-DIHYDROXYVITAMIN D3RECEPTORS IN HUMAN SKIN BIOPSIESJournal of Clinical Endocrinology & Metabolism, 1980
- Biological activity of 1α,24‐dihydroxycholecalciferol; A new synthetic analog of the hormonal form of vitamin DFEBS Letters, 1977