1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
- 1 August 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (15) , 4141-4147
- https://doi.org/10.1016/j.bmcl.2006.02.069
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor XaBioorganic & Medicinal Chemistry Letters, 2006
- Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitorsBioorganic & Medicinal Chemistry Letters, 2006
- Exosite-driven substrate specificity and function in coagulationJournal of Thrombosis and Haemostasis, 2005
- Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa InhibitorJournal of Medicinal Chemistry, 2004
- Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa InhibitorJournal of Medicinal Chemistry, 2003
- Visions & Reflections Factor Xa - a promising target for drug developmentCellular and Molecular Life Sciences, 2002
- Nonpeptide Factor Xa Inhibitors III: Effects of DPC423, an Orally-Active Pyrazole Antithrombotic Agent, on Arterial Thrombosis in RabbitsThe Journal of Pharmacology and Experimental Therapeutics, 2002
- Low-Molecular-Weight HeparinsNew England Journal of Medicine, 1997
- The international normalized ratio. A guide to understanding and correcting its problemsArchives of internal medicine (1960), 1994
- Methods of Determining Plasma and Tissue Binding of DrugsClinical Pharmacokinetics, 1992