Stimulation of liver growth and DNA synthesis by glucosylceramide
- 1 May 1988
- Vol. 23 (5) , 508-510
- https://doi.org/10.1007/bf02535529
Abstract
The nature of the growth‐stimulating effect of glucosylceramide was studied. Mice were injected intraperitoneally with emulsified glucosylceramide and conduritol B epoxide, an inhibitor of cerebroside glucosidase. Within one or two days, the liver grew 18–24%, as reported. Two enzymes involved in DNA synthesis also increased more than the weight. The total liver activity of thymidine kinase increased 46–73%, and the total activity of ornithine decarboxylase increased as much as 101%. It is suggested that elevated liver levels of glucocerebroside stimulate cell proliferation through a relatively direct mechanism.This publication has 20 references indexed in Scilit:
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