Effect of Hormones on Maintenance of Hyperplastic Alveolar Nodules in Mammary Glands of Various Strains of Mice2

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Abstract
Uniparous or multiparous mice of strains C3H/Crgl, C3H/Crgl/2, RIII/DmCrgl, DBA/2NCrgl, A/Crgl, and A/Crgl/3, which differ in their susceptibility to mammary cancer, were hypophysectomized-ovariectomized-adrenalectomized and treated with adrenocortical or adrenocortical + adenohypophysial hormones for 15 days. Examination of untreated intact mice showed that hyperplastic alveolar nodules were present in the mammary glands of all strains. Most nodules regressed, if the hypophysectomized-ovariectomized-adrenalectomized mice were treated with deoxycorticosterone acetate (DCA) + corticosterone acetate (B) only. However, treatments with DCA + B + mammotropin and DCA + B + somatotropin were found to be equally effective in maintaining the hyperplastic nodules at a level of development similar to that of intact mice of comparable strains, and initiated lactation in some of them. There were no significant strain differences in the response of hyperplastic alveolar nodules to these two hormone combinations. It is suggested that, although the hormone requirements for nodule formation may differ in different strains, the requirements for maintenance appear to be the same, regardless of strain.

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