CORRELATION OF NATURAL-KILLER CELL-FUNCTION WITH LEU-7 REACTIVITY IN PATIENTS WITH HUMORAL IMMUNODEFICIENCY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 56  (3) , 486-492
Abstract
The surface markers Leu-7, Leu-1, Leu-2a and Leu-3a were studied on lymphocytes of 54 healthy blood donors and 19 patients with humoral immunodeficiencies; the relative numbers of positive cells were compared with the natural killer cell (NK) activity. In controls, and in 12 of 19 patients (group A) the percentage of the Leu-7+ cells was positively correlated with NK activity. Seven of 19 patients had increased relative numbers of Leu-7+ cells and low NK activity (group B). In controls and group A patients .apprx. 40% of the Leu-7+ cells simultaneously expressed the cell markers Leu-1 and Leu-2a. In group B patients .apprx. 70% of the Leu-7+ cells carried T cell antigens. Furthermore, a distinct suppressor T cell predominance was noticed; the large granular lymphocytes of these patients showed morphological abnormalities.

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