PHARMACOKINETICS OF FOSFOMYCIN IN HEMODIALYZED PATIENTS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 23  (5) , 218-221
Abstract
The pharmacokinetics of fosfomycin, an original antimicrobial agent, were investigated in 11 voluntary hemodialyzed patients. Fosfomycin, 2 g, was administered i.v., 15 min before hemodialysis began in group 1 (6 patients), and just after hemodialysis in group 2 (6 patients). Blood samples were collected during 8 h (group 1) and during 44 h (group 2). Antibiotic concentrations were determined microbiologically. In group 1, half-life was 4.2 .+-. 0.27 h, total clearance 65.1 .+-. 7.1 ml/mn and clearance by hemodialyzer 103 .+-. 10 ml/mn. In group 2 plasma levels were 60 mg/l at the 44th h and half-life was 48.8 .+-. 17.5 h. These results suggest that fosfomycin is actively eliminated by the hemodialyzer in group 1, and largely retained between 2 dialysis sessions in group 2. As for therapy, i.v. administration of 2 g after dialysis and further administration after each succeeding session is proposed.

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