The rate of removal of amines from the blood

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Abstract
New methods are described (a) for estimating traces of amines in the blood and tissues and (b) for testing the efficiency with which amines are detoxicated in vivo in man. The method of estimation is suitable for amines such as [beta]-phenylethylamine or the aliphatic amines which are readily soluble in organic solvents: it depends on the colorimetric comparison of the yellow amine picrate in chloroform soln. Specimens of normal ox blood, guinea-pig blood and human blood contained less than 1 part per million of amines when tested by this method. The rate of detoxication of [beta]-phenylethyl-amine administered intraven. in man was estimated from the time taken for the blood pressure to return to normal to be of the order of 26 mg./kg. body wt./hr. The rate of detoxication of isoamylamine administered intraven. in man was estimated from the rate of removal from the blood to be of the order of 60-250 mg./kg./hr. or 4-15 g./hr. in a 60 kg. man.

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