Reactive oxygen species in cell signaling
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- 1 December 2000
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Lung Cellular and Molecular Physiology
- Vol. 279 (6) , L1005-L1028
- https://doi.org/10.1152/ajplung.2000.279.6.l1005
Abstract
Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of “oxidative stress” is thought to contribute to the pathogenesis of a number of human diseases including those of the lung. Recent studies have also implicated ROS that are generated by specialized plasma membrane oxidases in normal physiological signaling by growth factors and cytokines. In this review, we examine the evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated. Emerging concepts on the mechanisms of signal transduction by ROS that involve alterations in cellular redox state and oxidative modifications of proteins are also discussed.Keywords
This publication has 303 references indexed in Scilit:
- The Requirement of both Intracellular Reactive Oxygen Species and Intracellular Calcium Elevation for the Induction of Heparin-Binding EGF-like Growth Factor in Vascular Endothelial Cells and Smooth Muscle CellsBiochemical and Biophysical Research Communications, 1999
- Validation of Lucigenin as a Chemiluminescent Probe to Monitor Vascular Superoxide as Well as Basal Vascular Nitric Oxide ProductionBiochemical and Biophysical Research Communications, 1999
- Upregulated Expression of Fibroblast Growth Factor (FGF) Receptors by Transforming Growth Factor-β1 (TGF-β1) Mediates Enhanced Mitogenic Responses to FGFs in Cultured Human Lung FibroblastsBiochemical and Biophysical Research Communications, 1998
- Glutathione Regulation of Tumor Necrosis Factor-α-Induced NF-κB Activation in Skeletal Muscle-Derived L6 CellsBiochemical and Biophysical Research Communications, 1997
- Activation of Protein Kinase C by Oxidized DiacylglycerolsBiochemical and Biophysical Research Communications, 1995
- Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimuriumCell, 1985
- Reactive oxygen production, arachidonate metabolism and cyclic AMP in macrophagesBiochemical and Biophysical Research Communications, 1983
- The oxidative metabolism of arachidonic acid by purified cytochromes P-450Biochemical and Biophysical Research Communications, 1981
- Diffusion effects in the metabolism of hydrogen peroxide by rat liver peroxisomesJournal of Theoretical Biology, 1975
- Evidence for superoxide generation by NADPH-cytochrome C reductase of rat liver microsomesBiochemical and Biophysical Research Communications, 1972