Dopamine‐Induced Apoptosis Is Mediated by Oxidative Stress and Is Enhanced by Cyanide in Differentiated PC12 Cells
Open Access
- 6 June 2000
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 74 (6) , 2296-2304
- https://doi.org/10.1046/j.1471-4159.2000.0742296.x
Abstract
Dopamine (DA) oxidation and the generation of reactive oxygen species (ROS) may contribute to the degeneration of dopaminergic neurons underlying various neurological conditions. The prese...Keywords
This publication has 59 references indexed in Scilit:
- Nitrosation of Uric Acid by PeroxynitriteJournal of Biological Chemistry, 1998
- Synergistic Induction of DNA Strand Breakage Caused by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative DiseaseChemical Research in Toxicology, 1997
- Alterations in the distribution of glutathione in the substantia nigra in Parkinson's diseaseJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1997
- Dopamine Oxidation Generates an Oxidative Stress Mediated by Dopamine Semiquinone and Unrelated to Reactive Oxygen SpeciesJournal of Molecular and Cellular Cardiology, 1997
- Mechanisms of Dopamine-Induced Cell Death in Cultured Rat Forebrain Neurons: Interactions with and Differences from Glutamate-Induced Cell DeathExperimental Neurology, 1997
- Defects of cytochrome c oxidase in the substantia nigra of Parkinson's disease: An immunohistochemical and morphometric studyMovement Disorders, 1997
- Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic FactorsJournal of Neurochemistry, 1995
- Role of mitochondria in the etiology and pathogenesis of Parkinson's diseaseBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1995
- Mitochondrial Complex I Deficiency in Parkinson's DiseaseJournal of Neurochemistry, 1990
- Relationship between dopamine content and its secretion in PC12 cells as a function of cell growthBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985