FEVER RESPONSES TO BACTERIAL PYROGENS IN GUINEA PIGS AND APPLICATION FOR SCREENING OF ANTIPYRETIC AGENTS
Open Access
- 1 January 1968
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 18 (1) , 80-85
- https://doi.org/10.1254/jjp.18.80
Abstract
Graded fever responses by different dose levels were distinctly recognized in guinea pigs by the injection of TTG, a lipopolysac-charide prepared from Pseudomonas fluorescens and typhoid-para-typhoid vaccine. The screening of antipyretic effect was successfully carried out in these fevered guinea pigs. The antipyretic effects of indomethacin, phenylbutazone, flufenamic acid, aminopyrine, ace-tylsalicylic acid, paracetamol and quinine HC1 were demonstrated. The order of potency among these drugs in guinea pigs was similar to that in rabbits.This publication has 2 references indexed in Scilit:
- The rectal temperature of non-treated and drug-treated rat under unrestrainted conditionFolia Pharmacologica Japonica, 1965
- Pyretogenic effects of bacterial lipopolysaccharide and the assay of antipyretic drugs in ratsToxicology and Applied Pharmacology, 1963