Differentiation between pathogenic mechanisms of early and late phase of endotoxin shock
- 1 June 1966
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 210 (6) , 1451-1460
- https://doi.org/10.1152/ajplegacy.1966.210.6.1451
Abstract
Early phase of endotoxin shock (ES) in rabbits, characterized by a rapid transient fall in systemic arterial pressure (PA) [Pseudomonas psuedomallei] and a concomitant rise in right ventricular pressure (PRV) was induced only by rapid injection of large dose of endotoxin. Small doses did not produce these early changes but, after a latent period of 10-68 min., induced the gradual and irreversible fall in PA that characterizes late phase of ES. Increasing doses did not produce a gradual transformation of late into early phase. Severity of late phase was not related to that of early phase. Tachyphylaxis to anaphylactic shock (AS) suppressed early but not late phase. Anaphylactoid reaction prior to injection of endotoxin increased the severity of late phase only. A pressor response in PRV to small doses of acetylcholine was observed only during late phase. The differences between early and late phase reflect the existence of different pathogenic mechanisms that are not causally related. Excessive doses of endotoxin superimpose the AS-like syndrome of early phase over late phase. This may result in an exaggeration of the importance of immediate anaphylactic reactions in the pathogenesis of ES in man.This publication has 1 reference indexed in Scilit:
- Mechanism and significance of endotoxin-induced sensitization to acetylcholine in rabbitsAmerican Journal of Physiology-Legacy Content, 1964