Effect of Cyanide on Some Chlorpromazine Responses
- 1 March 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (3) , 635-636
- https://doi.org/10.3181/00379727-100-24725
Abstract
It is shown that chlorpromazine, like compound 48/80 which is a powerful histamine liberator, destroys mast cells in vivo and that cyanide prevents this disruption. Furthermore cyanide also prevents some of the hypothermic effect of chlorpromazine. Consequently, this study may be regarded as further evidence to a possible relationship between mast cell disruption and hypothermia caused by chlorpromazine.Keywords
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