Cyclic AMP-sensitive ion channels in olfactory receptor cells

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Abstract
Membranes from rat olfactory epithelial homogenates were incorporated into planar bilayers by a tip-dipping method. Analysis of single-channel currents indicate the existence of a cation channel activated by the addition of adenosine 3′,5′monophosphate (cAMP). The activity did not require exogenous ATP or GTP. The current-voltage relationship for the single-channel fluctuations gave a slope conductance of 32 ± 5 pS and a reversal potential of −5 ±4 mV. Forskolin elicited an increase in patch conductance similar to that produced by cAMP. This response required the presence of ATP and could be enhanced by theophylline.

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