Hereditary Renal Carcinoma and Chromosomal Defects

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Abstract
To the Editor: In a cytogenetic study of a family prone to renal-cell carcinoma, Cohen et al. (Sept. 13, 1979, issue)1 described five affected members with a balanced reciprocal translocation between chromosomes 3 and 8 in peripheral leukocytes. To examine rhe possibility that a chromosomal mutation at a common gene locus may exist among other patients who are genetically predisposed to this tumor, we studied the occurrence of chromosomal anomalies in three groups of patients with renal carcinoma who would seem most likely to possess a gene for tumor susceptibility. These were patients with a family history of this . . .