VIII Nerve in Experimental Lead Poisoning
- 1 January 1969
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 68 (1) , 85-89
- https://doi.org/10.3109/00016486909121546
Abstract
Forty healthy guinea pigs were poisoned with repeated peritoneal injections of lead acetate. After 7 weeks the animals were sacrificed and the inner ear with VIII nerve were examined histologically. The lead level in the blood was estimated in all animals after poisoning and in 10 healthy guinea pigs (control group). The sensory cells of the inner ear, the spiral and vestibular ganglion cells appeared to be normal. The VIII nerve in the majority of poisoned animals showed segmental deniyelina-tion and axonal degeneration. Theories on etiology and pathogenesis of the neuropathological changes in lead poisoning are discussed.Keywords
This publication has 5 references indexed in Scilit:
- Chronic Peripheral Neuropathy Produced by Lead Poisoning in Guinea-PigsJournal of Neuropathology and Experimental Neurology, 1966
- The distribution of lead after intravenous injection in the tissues of the rabbit, and in tumour-bearing miceBritish Journal of Cancer, 1965
- LEAD IN RELATION TO DISSEMINATED SCLEROSISBrain, 1950
- LEAD AS A POSSIBLE CAUSE OF MULTIPLE SCLEROSISArchives of Neurology & Psychiatry, 1934
- Lead poisoningPsychiatric Quarterly, 1932