Broad Thumbs and Toes and Mental Retardation

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Abstract
IN 1963 Rubinstein and Taybi1 described seven children with mental retardation, broad thumbs and toes, and facial abnormalities. The following year Coffin2 described six additional children and concluded that the condition was a distinct entity of unknown cause. The purpose of this paper is to report two children with this syndrome and to describe certain dermatoglyphic patterns which may be of diagnostic significance. Report of Cases Case 1.—This girl was born on July 1, 1963. She was the first born child of the family. Pregnancy and delivery were normal and the birth weight was 8 lb (3,629 gm). Both parents were 29 years of age when she was born. The maternal grandmother was 36 years of age when the mother of case 1 was born and had one miscarriage thereafter. The paternal grandmother had two offspring 17 years apart and the father of case 1 was the younger

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