Ca2+ Homeostasis in Vascular Smooth Muscle
- 1 January 1995
- journal article
- review article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 32 (4) , 207-219
- https://doi.org/10.1159/000159095
Abstract
The free intracellular calcium concentration is an important link in the excitation-contraction coupling mechanism of vascular smooth muscle. In this review, some current topics about vascular smooth muscle as regards Ca2+ storage, Ca2+ release, Ca2+ extrusion and Ca2+ regulation are discussed. Particular attention is paid to Ca2+ mobilized from the sarcoplasmic reticulum, the physiologically important Ca2+ reservoir in vascular smooth muscle. This occurs through two Ca2+ release channels: the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor; the characteristics, function and control of these two receptors are summarized. Emphasis is also placed on a role of the nucleus as a potential Ca2+ storage site.Keywords
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