A NEW BIOLOGICAL TARGET OF FUROCOUMARINS: PHOTOCHEMICAL FORMATION OF COVALENT ADDUCTS WITH UNSATURATED FATTY ACIDS
- 1 April 1988
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 47 (4) , 537-541
- https://doi.org/10.1111/j.1751-1097.1988.tb08841.x
Abstract
Abstract— Furocoumarins, potent skin therapy and tanning agents, form covalent adducts in a photochemical reaction with unsaturated fatty acids. These adducts and the chemical kinetics of their formation have been characterized by chromatography, isotopic tracers, electronic absorbance and fluorescence spectroscopy and mass spectrometry. Adduct formation does not require oxygen. The quantum yield of adduct formation in ethanol or methanol‐water solutions is comparable to the quantum yield for formation of furocoumarin‐thymine adducts in DNA.Keywords
This publication has 25 references indexed in Scilit:
- Long-term risks of psoralen and UV-A therapy for psoriasisArchives of Dermatology, 1983
- Sunscreens: Topical and systemic approaches for protection of human skin against harmful effects of solar radiationJournal of the American Academy of Dermatology, 1982
- Psoralen Photochemistry and Nucleic Acid StructureJournal of Investigative Dermatology, 1981
- PSORALENS, UVA (PUVA) AND PHOTOCARCINOGENESISPhotochemistry and Photobiology, 1981
- PSORALEN PHOTOCHEMISTRYAnnual Review of Biophysics and Bioengineering, 1981
- Evaluation and Treatment of Mycosis Fungoides LymphomaInternational Journal of Dermatology, 1980
- Psoralen Photochemotherapy of Cutaneous DisordersAnnual Review of Pharmacology and Toxicology, 1980
- PHOTOCHEMISTRY AND PHOTOBIOLOGY OF PSORALENSPhotochemistry and Photobiology, 1979
- Possible defects in triacylglycerol and phosphatidyl- choline metabolism in psoriatic epidermisBritish Journal of Dermatology, 1978
- Free Fatty Acids of the Skin Surface and Barrier Zone in Normal and Abnormal KeratinizationJournal of Investigative Dermatology, 1963