Direct Effects of Purified Staphylococcal Toxic Shock Syndrome Toxin 1 on Myocardial Function of Isolated Rabbit Atria
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 11 (Supplement) , S313-S315
- https://doi.org/10.1093/clinids/11.supplement_1.s313
Abstract
Toxic shock syndrome is associated with reversible cardiomyopathy. The cardiac dysfunction may be mediated by toxic shock syndrome toxin 1 (TSST-l), an exotoxin generated by Staphylococcus aureus. However, the effects of purified TSST-l on cardiac function are unknown. In a study of the toxin's effect on myocardial function, TSST-I (200 ng/mL) was added to muscle baths containing isolated rabbit atria. TSST-I caused time-dependent inhibition of developed force (systolic function) but did not alter resting force (an index of muscle stiffness or cardiac compliance). These data show that TSST-I can directly inhibit myocardial function, but the significance of this effect in patients with toxic shock syndrome remains to be determined.Keywords
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