PREVENTION OF OXALATE UROLITHIASIS BY SOME COMPOUNDS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 15  (6) , 493-495
Abstract
Male Wistar rats were fed a basal diet and an oxalate calculi-producing diet (CPD). The CPD was the basal diet containing 3% glycolic acid. Sodium pyruvate, DL-alanine, .alpha.-keto glutaric acid, thiamine pyrophosphate and L-glutamic acid were added to the CPD to determine their effectiveness in preventing calculi formation. The effectiveness of methyl glyoxal was determined by adding it to the drinking water. Rats fed CPD for 4 wk developed calculi in the ureters, bladder, renal tubules and/or renal pelvis and papilla. Rats in groups fed alanine and/or pyruvate had no calculi in their renal tubules or ureters; additionally, these rats had a significant reduction in incidence and amount of deposits in the renal pelvis and bladder. Rats in groups fed .alpha.-keto glutaric acid, thiamine pyrophosphate, L-glutamic acid and methyl glyoxal developed equally or more severe oxalate urolithiasis than those on CPD alone. Either pyruvate or alanine at appropriate levels may be beneficial in preventing oxalate urolith formation.

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