Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders
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Open Access
- 4 December 2005
- journal article
- clinical trial
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (1) , 28-30
- https://doi.org/10.1038/nn1611
Abstract
To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.Keywords
This publication has 15 references indexed in Scilit:
- EEG evidence for mirror neuron dysfunction in autism spectrum disordersPublished by Elsevier ,2005
- Gaze fixation and the neural circuitry of face processing in autismNature Neuroscience, 2005
- Impaired motor facilitation during action observation in individuals with autism spectrum disorderCurrent Biology, 2005
- The brain response to personally familiar faces in autism: findings of fusiform activity and beyondBrain, 2004
- THE MIRROR-NEURON SYSTEMAnnual Review of Neuroscience, 2004
- Activation of the fusiform gyrus when individuals with autism spectrum disorder view facesNeuroImage, 2004
- Abnormal imitation‐related cortical activation sequences in Asperger's syndromeAnnals of Neurology, 2004
- Functional imaging of face and hand imitation: towards a motor theory of empathyNeuroImage, 2004
- Cortical Mechanisms of Human ImitationScience, 1999
- Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disordersJournal of Autism and Developmental Disorders, 1994