Joint hypermobility and genetic collagen disorders: are they related?
Open Access
- 1 February 1999
- journal article
- review article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 80 (2) , 188-191
- https://doi.org/10.1136/adc.80.2.188
Abstract
A hypermobile joint is one whose range of movement exceeds the norm for that individual, taking into consideration age, sex, and ethnic background. The maximal range of movement that a joint is capable of is determined by the tightness or otherwise of the restraining ligaments. Thus, the primary cause of hypermobility is ligamentous laxity. This is inherent in a person’s make up and is determined by their fibrous protein genes. Of particular importance in this respect are the genes that encode collagen, elastin, and fibrillin.Keywords
This publication has 25 references indexed in Scilit:
- EXTRA-ARTICULAR FEATURES OF BENIGN JOINT HYPERMOBILITY SYNDROMERheumatology, 1996
- THE MARFAN SYNDROME: JOINT AND SKIN MANIFESTATIONS ARE PREVALENT AND CORRELATEDRheumatology, 1995
- HIGH PREVALENCE OF JOINT LAXITY IN WEST AFRICANSRheumatology, 1994
- SPECIAL INTEREST GROUP FOR JOINT HYPERMOBILITYRheumatology, 1993
- Joint hypermobility in adults referred to rheumatology clinics.Annals of the Rheumatic Diseases, 1992
- The Response to Local Anaesthetics (EMLAR-cream) as a Clinical Test to Diagnose between Hypermobility and Ehlers Danlos Type III SyndromeScandinavian Journal of Rheumatology, 1991
- Type I procollagen: The gene‐protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissueAmerican Journal of Medical Genetics, 1989
- Type III collagen mutations in Ehlers Danlos Syndrome type IV and other related disordersClinical and Experimental Dermatology, 1988
- Hypermobility: features and differential incidence between the sexesArthritis & Rheumatism, 1987
- Articular mobility in an African population.Annals of the Rheumatic Diseases, 1973