SQ 26,776: in-vitro antibacterial activity and susceptibility to -lactamases

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Abstract
The in-vitro antibacterial activity of SQ 26,776 (SQ) was assessed against recent clinical isolates of common bacteria and also against reference strains that produced known β -lactamases. The compound was active against enterobacteria with nearly all isolates inhibited by 2 mg/l. It possessed particularly high activity against Morganella morganii , Proteus spp. and Providencia spp. (MICs mostly 0.016 to 0.03 mg/l). SQ had moderate activity against Acinetobacter sp. (MICs mostly 4–32 mg/l) and Pseudomonas aeruginosa (MICs mostly 4–32 mg/l) but, in general, its activity against other pseudomonads was poor. The compound was highly active against Haemophilus influenzae (MICs 0.06–0.25 mg/l) and Neisseria gonorrhoeae (MICs 0.016–0.5 mg/l). It was inactive against most staphylococci and streptococci, though Lancefield group A streptococci were less resistant (MICs 8–16 mg/l), and it had poor activity against most anaerobes though many isolates of Bacteroides spp. (but not the Bact. fragilis group) and Fusobacterium spp. were sensitive. Inoculum effects on MICs of the compound were generally small and MBCs were similar to the MICs. SQ was resistant to most β -lactamases but it was hydrolysed slowly by some enzymes, particularly cefuroxime-hydrolysing enzymes from Klebsiella 1082E (K1), Proteus vulgaris and Bacteroides spp.

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