Rapid Assessment of P-Glycoprotein Inhibition and Induction in Vitro
- 1 January 2003
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 20 (8) , 1177-1183
- https://doi.org/10.1023/a:1025092829696
Abstract
Purpose.Using rhodamine123 (RH123) cell exclusion, 17 clinically used compounds were screened for their inhibitory effect on P-glycoprotein (P-gp), which was compared with the drugs' inhibitory...Keywords
This publication has 23 references indexed in Scilit:
- Microplate Screening of the Differential Effects of Test Agents on Hoechst 33342, Rhodamine 123, and Rhodamine 6G Accumulation in Breast Cancer Cells that Overexpress P–GlycoproteinSLAS Discovery, 2002
- Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposureBritish Journal of Pharmacology, 2001
- Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell lineJournal of Pharmaceutical Sciences, 2001
- P‐glycoprotein Interactions of Nefazodone and Trazodone in Cell CultureThe Journal of Clinical Pharmacology, 2001
- Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interactionClinical Pharmacology & Therapeutics, 2000
- The role of intestinal P-glycoprotein in the interaction of digoxin and rifampinJournal of Clinical Investigation, 1999
- Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with RitonavirThe Journal of Clinical Pharmacology, 1998
- The barrier function of CYP3A4 and P-glycoprotein in the small bowelAdvanced Drug Delivery Reviews, 1997
- Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agentsCancer Letters, 1996
- Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.Proceedings of the National Academy of Sciences, 1989