Nucleotide Sequence Coding for the Flavoprotein Subunit of the Fumarate Reductase of Escherichia coli

Open Access
Publisher Website
Google Scholar
Abstract
The nucleotide sequence of the frdA gene, which encodes the flavoprotein subunit of the fumarate reductase, of Escherichia coli, has been determined. A polypeptide of Mr= 66052, containing 602 amino acid residues, is predicted. In composition the FrdA protein strongly resembles the flavoprotein subunits of two succinate dehydrogenases. Moreover, a sequence of nine consecutive residues is common to the flavoprotein subunits from fumarate reductase and the beef heart succinate dehydrogenase. This sequence contains a histidyl residue which probably serves as the site for attachment of the FAD cofactor to the reductase.