Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D
Open Access
- 15 July 2004
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 173 (2) , 1078-1084
- https://doi.org/10.4049/jimmunol.173.2.1078
Abstract
We characterized two novel members of the RAET1/ULBP gene cluster, RAET1E and RAET1G. The encoded proteins were similar to the ULBP in their class I-like α1 and α2 domains, but differed in that, instead of being GPI-anchored, their sequences were type 1 membrane-spanning molecules. Both proteins were capable of being expressed at the cell surface. Both proteins bound the activating receptor NKG2D, and RAET1G bound the human CMV protein UL16. The expression of diverse NKG2D-binding molecules in different tissues and with different properties is consistent with multiple modes of infection- or stress-induced activation.Keywords
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