HINDERED CIS ISOMERS OF VITAMIN A AND RETINENE: THE STRUCTURE OF THE NEO-B ISOMER

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Abstract
Neo-B isomer of vitamin A and retinene, a hindered cis form, is the precursor of the visual pigments rhodopsin and iodopsin. This paper shows it to be a monocis isomer, therefore either 7 cis or 11-cis. The 11-cis isomer was synthesized and found to possess very different properties from neo-b. It may be called "neo-c." Neo-b isomer must therefore be 7-cis. Its properties are in specific agreement with this structure. The formation of theneo-b isomer raises special problems chemically and physiologically. Nothing is known of its biological occurrence or function outside the eye.

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