Applications of the Baylis-Hillman Adducts in Organic Synthesis: A Facile Synthesis of [E]-α-Cyanocinnamyl Alcohols and [E]-α-Cyanocinnamic Aldehydes
- 1 October 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (10) , 1630-1632
- https://doi.org/10.1055/s-1999-2893
Abstract
Aqueous sulfuric acid mediated transformation of the Baylis-Hillman adducts, i.e. 3-aryl-3-hydroxy-2-methylenepropanenitriles, into [E]-α-cyanocinnamyl alcohols and subsequent oxidation with PCC leading to the formation of stereochemically pure [E]-α-cyanocinnamic aldehydes, which represents an efficient alternative route to the Knoevenagel condensation reaction, is described.Keywords
This publication has 0 references indexed in Scilit: