PLASMA NICOTINE PHARMACOKINETICS IN DOGS AFTER INTRAVENOUS ADMINISTRATION - DETERMINATION BY RADIOIMMUNOASSAY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (2) , 267-277
Abstract
Nicotine plasma levels in dogs were examined by radioimmunoassay after i.v. administration of S-nicotine (100 .mu.g/kg). After a rapid decline of nicotine level in plasma immediately following the injection, retention of the level was observed until 30 min. From that point the plasma level decreased monoexponentially. A biological half life (t1/2,.beta.) of 0.61 h in dogs was similar to that in man and 1/2 of that in rats. Total body clearance (TBC) and apparent volume of distribution (Vd,.beta.) in dogs were about 1/5 of that rats. The results suggested that nicotine does not distribute in dogs are readily as in rats. Similarity in a biological half life nicotine in dogs and humans suggested that the dog may be a better experimental model than the rat in the investigation of pharmacokinetic parameters for nicotine.

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