Primary amines inhibit the triggering of B lymphocytes to antibody synthesis.

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Abstract
Transglutaminase enzyme activity was demonstrated in murine splenic B lymphocytes. Preincubation of cell cultures with primary amines that are known substrates for transglutaminase inhibited the triggering of murine B lymphocytes to form clones of antibody-producing plasma cells. B cells could be rescued from this inhibition by incubating cultures with anti-immunoglobulin or multivalent antigens under nonstimulatory conditions. Rescue of B cells exhibited the same requirements as stimulation, which suggests that rescue is a dynamic process and not simply a receptor-ligand binding event. Primary amines appeared to inhibit an early, T cell-independent event in the B cell activation pathway, which was not sufficient to trigger B cells to form antibody-producing clones. Subsequent receptor-mediated events, required to further trigger B cells, were not inhibited by the presence of primary amines.

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