Studies on Enzyme Concentration and Adaptation in Human Liver and Adipose Tissue

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Abstract
A series of potentially adaptive enzymes, which have been related to the control of metabolic pathways in rats, were studied in human liver and adipose tissue. Under the conditions of the experiments used, no changes in enzyme concentration from normal were found in adipose tissue from obese individuals, either in the usual state or after a period of starvation and refeeding. Similar results were obtained in diabetic patients treated with insulin for a long time period. In a series of hyperthyroid patients, the malic enzyme in adipose tissue was found to be elevated; however, treatment of normal volunteers with doses of triiodothyronine equivalent to twice normal thyroid maintenance dose for 2 months was without effect. An important aspect related to the control of lipogenesis in human adipose tissue was the finding of a virtual absence of the citrate cleavage enzyme.