Cardiac Sarcolemmal Substrate of the cGMP-Dependent Protein Kinase
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Membrane Biochemistry
- Vol. 7 (3) , 135-142
- https://doi.org/10.3109/09687688709039990
Abstract
Cardiac sarcolemmae from guinea pig ventricles were purified and incubated with cGMP-dependent protein kinase. In the presence of the purified kinase plus 10−5M cGMP or 8-Br-cGMP, a protein of approximately 50 kD, (Kilodalton) was phosphorylated. This membrane-associated cGMP-dependent protein kinase substrate is similar in MW to the regulatory subunit of the cAMP-dependent protein kinase, which is known to be a substrate for the cGMP-dependent protein kinase. Thus, this substrate, the identity of which remains to be proven, may be a possible mediator of cGMP-mediated control of cardiac function.This publication has 16 references indexed in Scilit:
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