Reticuloendothelial Granuloma

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Abstract
During recent years considerable attention has been given to the morbid anatomy of the reticuloendothelial system, whereas relatively little attention has been paid to the biochemical changes in the diseases involving this type of tissue. Although disorders in this category represent an interesting pathological entity, the etiology and pathogenesis are unknown. The occurrence of transition types tends to complicate the clinical picture; nevertheless, it is possible to differentiate three rather distinct entities. Letterer-Siwe disease (L-S): This disorder was named, in 1936, by Abt and Denenholz,1who cited the reports of Letterer2(1924) and Siwe3(1933). Usually it is characterized by generalized reactions with fever, anemia, hepatosplenomegaly, hemorrhagic manifestations, skin eruptions, lymphadenopathy, and skeletal lesions. Hand-Schüller-Christian disease (H-S-C): This eponym began in 1893, with a clinical description by Hand,4and continued in 1915, when Schüller5pointed out the peculiar radiological appearance of the skull defects, and