Localization of the CAMKG gene encoding γ isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14

1 January 1994

journal article
Published by S. Karger AG in Cytogenetic and Genome Research

Vol. 66 (2) , 113-116
https://doi.org/10.1159/000133679

Abstract

Multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) is an enzyme mediating calcium-dependent signal transduction pathways. CaM kinase exists in a variety of isoforms, each with a distinct tissue-specific expression pattern, that enables the kinase to regulate multiple functions in mammalian systems. Here we report the chromosomal localization of the previously cloned human γ-CaM kinase gene (CAMKG). By using a mapping panel of human × Chinese hamster somatic cell hybrid lines and fluorescence in situ hybridization, we have assigned human CAMKG to chromosome 10q22. We have partially cloned the murine γ-CaM kinase gene and mapped it Camkg to mouse chromosome 14 by analyzing a panel of mouse × rodent somatic cell hybrid lines. A recessive gene, asa, implicated in the control of autoimmune response, is located within the predicted region for Camkg.

Keywords

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