XERODERMA-PIGMENTOSUM - H2O2 FORMATION AND CATALYTIC ACTIVITY DURING THE EVOLUTION OF THE SKIN CELLS - APPLICATION TO AN EARLY DIAGNOSIS AND TO A TENTATIVE TREATMENT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 296  (18) , 845-850
Abstract
In Xeroderma pigmentosum (XP) a genetic-recessive UV-hypersensitive disease an accumulation of photoproduced H2O2 was found in skin cells accompanied by a breakdown of the catalatic activity. Both disorders intensified as the disease progressed. Concomitantly with these processes, one electrochemical peak of urine decreased. By the time epitheliomas appeared, this peak was no longer detectable. Several applications to the skin of a cream containing catalase seemed to prevent the formation and the evolution of neoplasic tumors during the treatment.

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