Action of Triethanomelamine (TEM) on Early Stages of Chick Embryos

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Abstract
Of many closely related compounds investigated recently from the point of view of cytotoxity and tumour-inhibiting properties 2,4,6-tri-(ethyleneimino)-1,3,5-triazine (called also triethanomelamine or TEM) proved to be the most effective substance against the Walker rat carcinoma. First descriptions of this fact were published in 1950 (Buckley et al. and Burchenal et al.). Also in 1950 appeared the publication of the first results of the clinical application of TEM at the First International Cancer Congress (Mueller & Miller). Later on Karnovsky et al. (1951) and Petersen et al. (1951) recommended procedures for parenteral and oral administration of this substance in clinical treatment. Very recently TEM has been introduced in a commercial form for oral and parenteral administration in cases of leukaemia, Hodgkin’s disease, polycythaemia vera, and other neoplastic conditions.