A Simple, Chiral-Pool-Independent Synthesis of Enantiomerically Pure Alanine-Derived α-Amino Aldehyde Acetals

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Abstract
Enantiomerically pure (R)- or (S)-1,1-dialkoxy-2-propanamines 5 are obtained in good chemical and optical yields, by asymmetric reduction of chiral imines prepared from 1,1-dialkoxy-2-propanones, using (R)- or (S)-1-phenylethylamine ((R)- or (S)-2) as an inexpensive, efficient chiral auxiliary.

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